![]() ![]() ![]() Histological score, regional compliance, wet-to-dry ratio, and inflammatory infiltrate were assessed to evaluate lung injury at the end of the study. Methods: Healthy pigs underwent left UPAL and were allocated for 48 h to the following: Volume-controlled ventilation (VCV) with V T 10 ml/kg (injury, n = 6) VCV plus 5% FiCO 2 (FiCO 2, n = 7) VCV with V T 6 ml/kg (low V T, n = 6) VCV plus additional circuit dead space (instrumental V D, n = 6). hypercapnia induced by low tidal volume ventilation or instrumental dead space. This study aims to compare the effects and mechanisms of FiCO 2 vs. The addition of 5% CO 2 to the inspiratory gas (FiCO 2) prevents the injury, but it is not clear whether lung protection is a direct effect of CO 2 inhalation or it is mediated by plasmatic hypercapnia. Possible mechanisms include redistribution of ventilation toward the non-ligated lung and hypoperfusion of the ligated lung. 6Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italyīackground: Unilateral ligation of the pulmonary artery (UPAL) induces bilateral lung injury in pigs undergoing controlled mechanical ventilation.5Center for Preclinical Research, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.4Division of Thoracic Surgery and Lung Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.3Department of Biomedical Surgical and Dental Sciences, University of Milan, Milan, Italy.2Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.1Department of Anesthesia, Critical Care and Emergency, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. ![]() Elena Spinelli 1 Antonio Pesenti 1,2 Gianluca Lopez 3 Anna Damia 2 Francesco Damarco 4 Erica Garbelli 2 Gaia Dal Santo 2 Alessio Caccioppola 1,2 Giorgio Giudici 2 Virginia Figgiaconi 2 Osvaldo Biancolilli 1 Michele Battistin 5 Caterina Lonati 5 Valentina Vaira 2,6 Lorenzo Rosso 2,4 Stefano Ferrero 3,6 Stefano Gatti 5 Tommaso Mauri 1,2 * ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |